TIANFU-CHEM - cephaeline hydrochloride
Platycodin D
CAS: 58479-68-8
Molecular Formula: C57H92O28
TIANFU-CHEM - cephaeline hydrochloride - Names and Identifiers
TIANFU-CHEM - cephaeline hydrochloride - Physico-chemical Properties
| Molecular Formula | C57H92O28 |
| Molar Mass | 1225.34 |
| Density | 1.56 |
| Melting Point | approximate 217℃ (dec.) |
| Solubility | Insoluble in water, easily soluble in methanol, ethanol and other organic solvents and dilute alkali. |
| Appearance | White crystalline powder |
| pKa | 12.76±0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.659 |
| MDL | MFCD09952590 |
| Physical and Chemical Properties | White crystal, soluble in water, methanol, ethanol, insoluble in acetone, ethyl acetate and other low polar solvents, derived from platycodon grandiflorum. |
TIANFU-CHEM - cephaeline hydrochloride - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
TIANFU-CHEM - cephaeline hydrochloride - Reference
| Reference Show more | 1. Wen Yuping, golden iron. Effects of barrel temperature and water content on expansion characteristics and platycodin D content of extruded Platycodon grandiflorum [J]. Agricultural Journal of Yanbian University, 2019, 041(003):83-88. 2. Zhu Lifen, Wang Bing. Protective effect of platycodin D against Candida albicans infection in oral mucosal epithelial cells [J]. Chinese Journal of pathophysiology, 2017, 30 (1):161-165. 3. Zhao Ruolin, Zhou Kunfu, Zhang Xu, Chen Meijuan. Mechanism of platycodin-D inhibiting adhesion, invasion and migration of non-small cell lung cancer H460 and A549 cells [J]. Chinese pharmacological Bulletin, 2015,31(02):241-247. 4. Ma Linlin, He Hui, Zhang Shike, et al. Effect and mechanism of platycodin-D on apoptosis of Hela cells [J]. Journal of Modern integrated Chinese and Western medicine, 202029 Vol. 22, pages 2429-2436, ISTIC CA, 2020. 5. Zeng Jing, Kai, Guo Qing. Comparison of characteristics, extract, platycodin D content and HPLC fingerprint of Platycodon grandiflorum from different areas [J]. Chinese Journal of Experimental prescriptions, 2017, 23(24):62-70. 6. Wang Ju, Li Long, Zeng Jiashun. Effect and mechanism of platycodin D on proliferation and apoptosis of MH7A cells [J]. Journal of Guizhou Medical University, 2020,45(10):1149-1155. 7. Wang Ju, Li Long, Zeng Jiashun. Effect of platycodin D on migration and invasion of MH7A cells and its mechanism [J]. Guizhou Medical Journal, 2020,44(10):1515-1517 1681. 8. Ma Linlin, He Hui, Zhang Shike, Li Wei. Effect and mechanism of platycodin-D on apoptosis of Hela cells [J]. Journal of Modern integrated Chinese and Western medicine, 2020,29(22):2429-2436. 9. Zhang, Chi, et al. "Components study on antitussive effect and holistic mechanism of Platycodonis Radix based on spectrum-effect relationship and metabonomics analysis." Journal of Chromatography B 1173 (2021): 122680.https://doi.org/10.1016/j.jchromb.2021 10. [IF=3.565] Ruolin Zhao et al."Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways."J Cancer. 2015; 6(7): 623-631 11. [IF=4.932] Ruiqi Guo et al."Anti-inflammatory effects of Platycodin D on dextran sulfate sodium (DSS) induced colitis and E. coli Lipopolysaccharide (LPS) induced inflammation."Int Immunopharmacol. 2021 May;94:107474 12. [IF=4.821] Xiangwei Chang et al."Untargeted metabolomics approach reveals the tissue-specific markers of balloon flower root (Platycodi Radix) using UPLC-Q-TOF/MS."Microchem J. 2021 Sep;168:106447 13. [IF=3.935] Tong Xie et al."A post processing strategy to score and rank the annotation confidence of saponins in natural products by integrating MS2 spectral similarity and fragment interpretation."J Pharmaceut Biomed. 2021 Sep;204:114291 14. [IF=3.205] Chi Zhang et al."Components study on antitussive effect and holistic mechanism of Platycodonis Radix based on spectrum-effect relationship and metabonomics analysis."J Chromatogr B. 2021 May;1173:122680 15. [IF=2.311] Xiaoyu Zhang et al."Effects of Platycodin D on apoptosis, migration, invasion and cell cycle arrest of gallbladder cancer cells."Oncol Lett. 2020 Dec;20(6):1-1 |
TIANFU-CHEM - cephaeline hydrochloride - Reference Information
| biological activity | Platycodin D is a saponin compound isolated from orange stems. It is an activator of AMPK α and has anti-obesity activity. |
| target | AMPK α |
| chemical properties | white crystal, easily soluble in water, methanol, ethanol, insoluble in low-polarity solvents such as acetone and ethyl acetate, derived from Platycodon grandiflorum. |
| use | hypolipidemic, sedative, analgesic, antipyretic and vasodilating. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: direct stimulation of the oral cavity, throat, and gastric mucosa, reflexively increase the secretion of bronchial mucosa, thereby diluting sputum and easy to discharge. |
Last Update：2024-04-09 15:16:38
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View History
TIANFU-CHEM - cephaeline hydrochloride
3-AMINO-4,6-DIMETHYL-THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID AMIDE
4-三甲基-3-丁基卡因-1-醇
5,7-dihydroxy-2-(4-hydroR)-3,4,5-trihydroxy-6-(hydroxR,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]-4H-chromen-4-one (non-preferred name)
N-ALPHA-BENZYLOXYCARBONYL-N-BETA-ALLYLOXYCARBONYL-L-2,3-DIAMINOPROPIONIC ACID DICYCLOHEXYLAMINE
5-甲酰基尿嘧啶
3-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID METHYL ESTER
Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
4-(2-hydroxyethyl)piperazine-1-(2-hydr. prop.sulf.ac.) 1H2O
2-BROMO-N-6-ETHOXY-2-BENZOTHIAZOLYL-3-METHYL-BUTYRAMIDE
3-AMINO-4,6-DIMETHYL-THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID AMIDE
4-三甲基-3-丁基卡因-1-醇
5,7-dihydroxy-2-(4-hydroR)-3,4,5-trihydroxy-6-(hydroxR,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]-4H-chromen-4-one (non-preferred name)
N-ALPHA-BENZYLOXYCARBONYL-N-BETA-ALLYLOXYCARBONYL-L-2,3-DIAMINOPROPIONIC ACID DICYCLOHEXYLAMINE
5-甲酰基尿嘧啶
3-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID METHYL ESTER
Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
4-(2-hydroxyethyl)piperazine-1-(2-hydr. prop.sulf.ac.) 1H2O
2-BROMO-N-6-ETHOXY-2-BENZOTHIAZOLYL-3-METHYL-BUTYRAMIDE